This study examines the influences of demographic, socioeconomic, environmental, risk behavior and lifestyle factors on the physical and mental changes that lead to hypertension. This also includes the examination of ideology, beliefs and perceptions of several aspects in order to comprehend the contextual complexities of hypertension patients. Both quantitative and qualitative methods were used in this study. Secondary data from the Kanchanaburi project was used in the quantitative part. The project was to study the population of Kanchanaburi province with its 46,029 people or 12,477 households in 100 villages. Only those above 15 years old were selected, which is a total of 28,958 people. In the analysis of the influences of several contexts related to hypertension, Binary Logistic Regression was used. It was found that demographic, socioeconomic, environmental, risk behavior, lifestyle, physical and mental change variables are all related to hypertension except educational level, size of household and consumption of spicy food. These variables explained the incidence of hypertension at 24 % (p< .01). For the qualitative analysis, 5 hypertension patients from 5 villages, which were 25 people in total were selected. The data collection was conducted during 1 – 15 April, 2005. In addition, 5 people from the sample group were examined in their life histories using the Boolean analysis. It was found that there were many interesting factors especially morbidity factors interacting with one another in a complex manner. According to life history study, it was also found that all Subjects us took care of themselves inappropriately and did not have access to healthcare services. They did not have sufficient income and were even in debt. Many of them have risk behaviors such as consumption of high fat products, alcohol, and cigarettes. Many of them had several jobs had a strong desire for modern development of their own villages. They also had past memories and anxiety. Moreover, it was found that their beliefs about factors contributing to the severity of their morbidity were the beliefs of Karma or fate, meteorological characteristics, geographical characteristics, medication, moral support, health promotion and continuity of treatment. Conclusively, it can be summarized that the qualitative and quantitative results were both positively in accordance with each other. The qualitative study provided insight into the lifestyle of the patients in detail, and the contextaul complexities that lead to hypertension. It is suggested that individual health problems and solutions should be considered in the holistic aspect including socioeconomic and environmental dimension, or to try to understand “disease” from multidisciplinary approaches and through multidisciplinary professionals. In addition, the social welfare of chronic patients should be supported by having a community health center providing services in all four aspects including health promotion, prevention, treatment and rehabilitation. This depends on the situation and needs of each patient. This should be a proactive approach not a passive one.